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Zeta Uploader

Zeta Uploader is a free alternative to send big files that you can either use online or via software on your Windows machine. No info is given on the maximum file size that you can transfer.
Just upload your file, type the email address of your recipient and write a message for him / her. The service will generate a download link and send it inside an email message so that your receiver may collect the file. Optionally, you can set a date and a number of download after which your file will expire and password-protect your file.
http://www.zeta-uploader.com/en
SendGenie

SendGenie is a free software for Windows and Mac users to send very large files right from your desktop in a drag and drop fashion. SendGenie can send one or multiple files of any kind at once, but no info is given on the maximum file size that you can transfer.
Just download the software to your machine and drag and drop the file you want to send to the application window. Then type in the email address of your recipient. SendGenie will upload your file and send your recipient a download link to collect the file.
http://sendgenie.com/
FilePost

FilePost is a free large files transfer service whereby you can transfer up to ten big files up to a total of 250MB by using a customized email message or by creating a web folder that contains up to 50 files (100MB total).
To start, just go to the homepage of the service, select the option you prefer and then customize the sending forms accordingly. Each field you need to fill has a "?" next to it which, when clicked, will give you detailed information and assistance on what info you need to provide.
http://file-post.net/en/
FileChute

FileChute is a paid software for Mac that allows you to transfer files of unlimited size to any computer on the web. FileChute requires an FTP or WebDAV-accessible web server to work. Apple MobileMe service is a suitable option as well.
Once you associate FileChute with your web server, sending your large files will be completed with a simple drag and drop operation. Each upload file will then have a unique URL that you cna share via email, IM social network, in any way you like. FileChute is also available via an iPhone app ($2.99) and it is priced at $17.95 for a single-user license.
http://www.yellowmug.com/filechute/
FileShare HQ

FileShare HQ is a paid online service that is capable of sending large files up to 99GB in size. There is a free plan available that limits the usage of FileShare HQ to only two people and files that you can transfer are limited to 500MB in size.
To start, just log-in, upload your files and then invite other people via email to collect your uploads. All files you upload are stored in your personal online space, secured with encryption and persistently backed up. Registration is required to utilize the service and a 30-day free trial is available for each paid plan.
http://www.filesharehq.com/